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Tramadol is a unique compound with both a moderate mu-opioid effect (when compared to classic opioids) and a moderate monoaminergic effect (when compared to tricyclic antidepressants). Although possible, tolerance and dependence pose uncommon complications of the treatment. Out of the four main pain types, the action of Tramadol is not limited to neuropathic pain only but also includes suppression of noxious (nociceptive) pains.

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